Best Oscillating Multi Tool 2015

BEST OSCILLATING MULTI TOOL

Why oscillating tools are called multi tool?

The oscillating tool can perform various tasks therefore they are called multi tools. These tools are very popular these days and are faster and cheaper than ever.
Their versatility has made them the most important in power tool industry. The market of tools is changing so fast. New model are appearing hourly rather than yearly.

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CORDLESS TOOLS

Now you don’t have to depend on corded tools because cordless tools give you freedom to work anywhere especially in tight and difficult to reach places. You can enjoy using your tool without power cord because lithium ion battery maintains the same charge.

BEST OSCILLATING TOOLS

Research has been made in order to test the tools for evaluating and comparing their power, speed, noise level and other features.
Many people don’t know what to look for while buying a tool and what’s new in the market. The fact is that many people are facing difficulties about selecting the appropriate tool for themselves. This article features some of the best and latest tools in the market with details.

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• DEWALT DCS355D1 20V XR Lithium-Ion

DEWALT DCS355D1 20V XR Lithium-Ion is the most famous multi tool today. It comes with great features and reasonable price. Why this is on top?
It has an excellent run time when compared to other motors. Also, it has an easy system to change the attachments which saves your time and energy. Good grip of this device allows you to work efficiently without sweating. Moreover, bright LED gives you a clear view of dark surfaces.
Additionally, many attachments are available in this kit for performing your daily home tasks. Adaptor in this kit will allow you to attach blades from any manufacturer so you can use blade according to your comfort ability.

• Fein 72293768090 Kit Multi Master

This kit comes with wide range of accessories including longer scraper blade which improves your work speed. The blade quality is the best oscillating tool when compared to other blades. Another dominating feature of this device is that it doesn’t create smoke during use. It’s not cheap but with some good features you can still invest your money in this multi tool.

• Dremel MM30 2.5-Amp Multi-Max Oscillating Tool Kit

This is another famous tool. With 2.5 ampere battery it allows user to cut through hard materials. The plus point of this device is that its price is low and the features are great therefore investment in this tool is worthy.
The device has variable speed. This feature enables this tool to perform any function and makes it the real multi tool. It’s easy to handle and accessory system is quite easy. With faster cutting experience it has a great life. So the qualities of this device are hard to find in some other device.

These were some famous devices with excellent features available in market. You better know what type of qualities you prefer in your tool. Select the tool which you find comfortable and easy to handle.

The best Clamps & Vises 2015

In many ways, the best treatment for cancer is still extremely primitive because few agents specifically target only cancer cells. Basically, the treatment for cancer cells that are not surgically removed is similar to the treatment used many years ago for some parasite infections. The patient was poisoned with arsenic in the hope that the parasites would die before the patient did. Our options for killing cancer cells–ionizing radiation (X rays) and chemotherapy agents–are effective because cancer cells grow faster than normal cells. Unfortunately, radiation and chemotherapy also poison normal cells and cause severe side effects. In particular, fast-growing normal cells such as those in the immune system are also attacked; often, the dose of chemotherapy or radiation is limited by the collateral damage to the immune system.

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Last week a scientist, who is close friend, said that his wife’s white count was “basically zero” after the current treatment regimen for a breast tumor that had spread to the liver. Such treatment leaves the patient susceptible to infection and with anticancer defenses suppressed. In fact, radiation and chemotherapy agents are both capable of causing cancer, and patients treated with these regimens are at higher risk of developing a new form of cancer, even if the first cancer treatment is successful.

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Tumor-specific drugs

In an effort to increase the killing of tumor cells and decrease the killing of normal cells, many investigators are attempting to develop drugs that attack only cancer cells. Some antitumor agents, such as tamoxifen, specifically target biochemical pathways that are important in tumor cell growth. For example, the growth of many types of cancer cells is stimulated by the binding of the hormone estrogen with estrogen receptors of the cancer cell. Tamoxifen works by inhibiting the binding of estrogen to its receptor, thereby preventing estrogen-stimulated growth. Tamoxifen can also affect normal cells, however, because many of them have an estrogen receptor. Therefore, treatment by tamoxifen seems to increase the risk of later developing cervical or ovarian cancer. Further, tamoxifen does not kill tumor cells that have estrogen receptors but merely slows their growth.You can see detail home owner sets now

Unfortunately for us, cancer cells are just normal cells whose biochemical programs have gone berserk. Therefore, tumor cells usually have few unique biochemical pathways that could be targets for drugs. Targeting a drug to a tumor cell depends on the fact that tumor cells usually tend to make more of something that normal cells also make. For example, tumor cells that are growing rapidly need more of the basic molecular building blocks required to make new cells than normal cells do. Because cancer cells need fats (e.g, cholesterol) that are used to build cell membranes, they often have higher levels of a receptor for a fat carrier in the blood called low density lipoprotein (LDL). Therapy agents associated with LDL tend to concentrate at levels 7-10 times higher in cancer cells because they have more LDL receptors. Nevertheless, increasing the therapy agent delivered into cancer cells by that amount does not increase the efficiency enough to prevent attack on normal cells or raise the specific killing of cancer cells to a level to cure cancers. Other cells, such as those that make up blood vessels, also produce the LDL receptor, so they are susceptible to attack by this type of specific drug targeting.

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As the specific molecular alterations that cause cancer are further elucidated, rational drug design will improve the targeting of cancer cells while decreasing the effects on normal ones. The ultimate success of this approach is likely to be relatively disappointing, however, because of the similar biochemical and molecular compositions of tumor and normal cells.

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The fast pulsed, titanium-sapphire two-photon laser can also be focused within the tissue. This unique focusing effect allows very precise delivery of the light only to those areas where the effects in a tumor are desired.

Furthermore, the short, narrow, high-power pulses, when brought together through focusing the beam, can activate PDT agents at wavelengths shorter than near-infrared. For example, the PDT agent photofrin is best activated by light with a wavelength of 400 nanometers. The wavelength currently used is 630 nanometers, which allows a little tissue penetration but is very poor at activating the drug. The two-photon titanium-sapphire laser can be thought of as emitting two low-energy (near-infrared) photons, which equals one high-energy (UV) photon. (A photon is one unit of light, easily visualized as one basket or bunch of light.) By delivering laser light so that two photons arrive at the same place simultaneously, the equivalent of a 400-nanometer photon can act at the beam focus, even though only safe 800-nanometer light has traveled through the tissue to reach the focal point. A PDT agent such as photofrin cannot tell the difference between one UV photon or two simultaneous 800-nanometer photons, and the agent is activated and kills cells only in the focus of the two-photon, fast-pulsed laser beam. When used at 800 nanometers (instead of the 630 nanometers of conventional one-photon lasers), the fast-pulsed, two-photon laser is 100-1,000 times more efficient in activating photofrin, because it hits the 400-nanometer, high-absorbing area of the PDT agent. Therefore, the fast-pulsed two-photon laser is the light source of choice even for topical applications, because of its safety and efficiency in activating the agent. The combination of the two-photon, fast-pulsed laser with PDT agents may be the first cancer therapy without either surgery or side effects.

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When the two-photon lasers are used at very high energies, they can produce the same tissue-ablating effects as the conventional one-photon medical lasers. As they can be precisely focused using lenses and their intrinsic properties are safer to tissue, these lasers could well replace the conventional medical lasers as scalpels in surgery, correction of vision problems, cosmetic removal of facial lines, tattoo removal, and so forth.

Danger-free mammography

The risks associated with current mammography methods that use ionizing radiation are thought to be low. The usefulness of mammography to detect breast tumors in women 40-50 years old is currently a topic of intense debate, however. Though the risk may be low in younger women, the risks of mammography may outweigh any procedural usefulness.

The two-photon laser holds the promise of damage-free and pain-free imaging for breast tumors. The laser could be used in conjunction with approved drugs that are preferentially concentrated in tumor cells and, when stimulated by the 800 nanometers of two-photon light, produce lower-energy reemission photons that can be easily discriminated from the two-photon-exciting wavelengths. If the laser were operated in a scanning mode, the entire breast could be quickly surveyed, with any tumor showing as an active region illuminated by the reemission from the drug concentrated in the tumor.

My wife had her first mammography when she was 38. Until she had this procedure, I had never realized the degree of discomfort associated with the compression of the breast that current mammography methods required. She premised me something special if I invented something to remove the compression. As the two-photon laser can deeply penetrate tissue, I may already have earned whatever the “something special” turns out to be (a Corvette, I hope).

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Unfortunately, like the psoralens, hematophrins can only be used to treat cancers that are on some body surface, because the light required to activate these chemicals cannot penetrate tissue deeply. Therefore, PDT’s great potential to treat cancer without side effects had not been achieved until now. What was needed was a new type of light that could penetrate deep tissues but still activate the cancer-killing drugs.

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Sources of light for PDT

Agents that can be used for PDT generally require activation by light with a lot of energy, such as that associated with ultraviolet wavelengths. The use of ultraviolet light for treating tumors deep in the flesh is ruled out, however, not only because the tissue absorbs ultraviolet light but because the tissue can be damaged when it absorbs the light.

If the goal is to find wavelengths of light that penetrate the flesh and do not damage it, then the place to look is at wavelengths just longer than those of visible red light. To demonstrate why this is the best light for PDT, shine a household flashlight through the web of skin between your forefinger and thumb. The light coming through is red.

Tissue is pretty much transparent, if the right wavelength of light in the near-infrared is used. Because tissue cannot absorb this light, it can penetrate deep within the body. The wavelengths of light that are useful range from 700-2,500 nanometers ([10.sup.-9] meters). Near-infrared light cannot activate PDT agents that are activated by UV light, however. To get around this problem, investigators have been trying to develop new infrared-activated PDT agents. Most of these new agents have turned out to be highly poisonous and cannot be used. Further, development of a new drug requires about 7-17 years on average and an investment of $750 million to $1 billion. Therefore, for PDT to realize its true potential, a new type of light source was required.

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Two-photon PDT

Over the last five years, three researchers (Eric Wachter, Walt Fisher, and the author), working for most of that time at the Oak Ridge National Laboratory, have developed a new application for a special type of laser developed by Coherent Light of Santa Clara, California. The laser produces extremely fast pulses of near-infrared light. In 1996 the licensing rights for the new application were returned to the inventors, and they have founded PhotoGen to further develop it. The extremely fast, powerful pulses of laser light open the way for delivering powerful doses of energy deep into human tissue without damaging the outer layers.

One of these fast-pulsed lasers is a mode-locked titanium-sapphire laser that produces near-infrared light with a very high peak power. The laser emits a stream of discrete pulses of coherent light at the rate of 76 million pulses per second, and the duration of each pulse is extremely short at 200 femtoseconds (200 x [10.sup.-15] seconds). Because the pulses are so short and narrow, they are incapable of damaging tissue, even though the power per pulse (100,000 watts or higher) is extremely high. In comparison, a continuous beam of light from conventional lasers transfers enough energy to damage cellular components and kill cells. Even pulsed, near-infrared lasers can damage tissue if their pulses are on the order of 10 nanoseconds, ([10.sup.-9] seconds) or longer.

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In attempting to minimize the damage caused by surgical excision of breast tumors, investigators are developing what has been called minimally invasive therapy. For example, the lumpectomy procedure, which involves removing only the tumor and a relatively small area around it, is a step in this direction. Lumpectomy does much less damage than a radical mastectomy, in which the entire breast, plus some of the chest wall muscles and lymph nodes under the arm, is removed. Some reconstructive surgery to restore the breast’s natural shape may be required after the lumpectomy. Certainly, the natural goal is to develop cancer treatments that would require no surgery at all.

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Photodynamic therapy

One of the most promising approaches to reducing surgical invasion of the body is photodynamic therapy (PDT), which has been around for 6,000 years or so. The early Greeks noticed that if certain plants were eaten, exposure to the sun produced undesirable effects on the skin. The plants contain chemicals that, when activated by light, produce reactive products, which damage or kill cells by attacking cellular components such as the genetic material. Even today, psoriasis is treated with psoralens, which are similar to the chemicals found by the early Greeks in plants. Psoriasis patients are treated with psoralens and then the psoralens are activated using ultraviolet light (UV). Light-activated psoralens bind to genetic materials and other macromolecules, which then kill the cells. The therapeutic usefulness of psoralens is limited to topical applications, however, because the skin absorbs UV light, preventing deeper UV penetration. Absorption of UV light is well known to us all as sunburn. Besides the immediate effects of UV exposure, absorption of UV light results in damage to the genetic material that may, with repeated exposure result in skin cancer.

After exposure to the proper wavelengths of light, PDT agents such as those in the hematophrin family of drugs generate highly reactive chemicals called free radicals, which are very toxic to cells. [See “Free Radicals in Biological Systems,” THE WORLD & I, April 1988, p. 176, and “Oxygen Free Radicals in Medicine,” THE WORLD & I, May 1988, p. 167.] Hematophrins are used to treat skin cancer because they concentrate in cancer cells at levels 7-10 times higher than in normal cells. The hematophrins’ preference for cancer cells is thought to result from their association with fat carriers in the blood called low density lipoproteins (LDLs), since cancer cells have a higher number of receptors for LDLs than normal cells do. Treatment of cancer by such PDT agents as hematophrins is safer than treatment by chemotherapy or radiation, which can cause tumor cells’ virulence to increase if the treatment does not kill all the tumor cells the first time around. For example, somewhat like drug-resistant bacteria, the cancer cells may almost immediately become resistant to chemotherapy agents (multidrug resistance), and they may grow faster and be more invasive than the original cancer cells.

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Unlike chemotherapy and radiation, PDT cancer therapy does not induce increased cancer cell virulence. Further, because the PDT treatment produces cancer-killing compounds only in the area exposed to light and the range of those toxic compounds, once produced, is very limited, side effects are confined to a very small area. Side effects such as suppression of the immune system, hair loss, and disruption of the digestive tract do not occur when PDT is used to treat cancer.

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A new treatment for breast cancer will use a stream of pulsed laser light to activate cell-destroying reactions by drugs that naturally concentrate in the tumor.

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A laboratory technician approached me last year, saying, “You have to help me convince my sister to go to a real doctor.” The technician then told me that the sister had been diagnosed with breast cancer several years after she had breast-enlarging implants inserted. When the disease was diagnosed, it was confined to a small lump that hadn’t spread from the original site. In such cases, one option is surgery to remove only the tumor and a relatively small area around it, followed by a regimen of chemotherapy and radiation.

When the surgeon wanted to remove the implants, however, this woman refused surgical treatment. Instead, she went to someone whose “cure” consisted of massive doses of vitamin A. “The whites of my sister’s eyes are yellow,” the technician said, and “she has lumps in her armpit. I think the tumor is going to burst through the skin.”

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Treatment for breast cancer usually requires surgery that may or may not be confined to removing only the cancerous tissue. Surgery is often followed by radiation and chemotherapy to kill any cancer cells that surgery might have missed. Severe side effects may occur from radiation and chemotherapy treatments, and, if the surgery is radical, disfigurement may also result. Even the mammography methods used to detect breast cancer have some risk, since ionizing (X-ray) radiation is used to create the image.

Fortunately, with the advance of technology, a new, more benevolent approach to treating cancers of the breast and other areas has emerged from the research laboratories at Oak Ridge National Laboratory. A form of photodynamic therapy, the procedure uses the harmless, flesh-penetrating light from a new type of pulsed, fast laser to activate cancer-killing drugs that preferentially accumulate in the fast-growing cancer tissue. The procedure may be the first cancer treatment that does not require surgery or produce side effects. The same laser also can be used for imaging tumors in breast tissue without harming the tissue or increasing the risk of developing cancer.

Over 95 percent of breast cancer patients can be cured if the tumor is discovered before it can spread beyond the primary site. Unfortunately, the methods used to effect this amazing cure rate are still relatively primitive. Though breast-sparing surgical options exist, to paraphrase Dr. Susan Love, we still treat breast cancer by removing the first and most visible sign of a woman’s femininity and then poison her with toxic chemicals and radiation.

Apparently, the loss of the breast implants and the ordeal of chemical and radiation treatments that would follow surgery were too much for the technician’s sister to accept. As a laboratory researcher, I do not know if this is an isolated incident. Sadly, the success rate of treatment is much lower for patients whose disease has advanced out of the primary site. Today, I wonder if this woman’s two children still have a mother. I suspect they do not.